Normalized Post-Op CEA May Help Predict Colon Cancer Prognosis

Colon most cancers patients with multiplied preoperative carcinoembryonic antigen (CEA) ranges that normalize after resection are not at increased risk for poor prognosis, in keeping with a have a look at published on-line Dec. 21 in JAMA Oncology.

Tsuyoshi Konishi, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and co-workers assessed how pre- and postoperative tiers of serum CEA correlate with colon cancers outcomes. Retrospective analysis included 1,027 consecutive sufferers with colon most cancers (levels I to III) who underwent curative resection for colon adenocarcinoma between 2007 and 2014 at a single comprehensive most cancers center.

The researchers determined that sufferers with regular preoperative CEA had 7.4 percentage better three-12 months recurrence-unfastened survival (RFS) as opposed to the mixed cohorts with increased preoperative CEA (P = 0.01), despite the fact that that they had RFS just like that of patients with normalized postoperative CEA (P = 0.86). Patients with improved postoperative CEA had 14.9 percentage decrease RFS versus the combined cohorts with ordinary postoperative CEA (P = 0.001). There became an independent association between shorter RFS and multiplied postoperative CEA (threat ratio [HR], 2.0; 95 percentage confidence interval, 1.1 to 3.5), however shorter RFS become not related to normalized postoperative CEA (HR, 0.77; 95 percent self belief interval, 0.45 to 1.3) in multivariate analyses.

“Elevated preoperative CEA that normalizes after resection isn’t a trademark of bad prognosis,” the authors write. “Patients with increased postoperative CEA are at increased hazard for recurrence, especially inside the first twelve months after surgery.”

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