Obesity Linked to Adverse Events in Children With Leukemia

For children with acute lymphoblastic leukemia (ALL), weight problems is related to an increased chance for adverse occasions all through premaintenance chemotherapy, in keeping with a observe published inside the February issue of Pediatric Blood & Cancer.

Chelsea K. Meenan, from the University of Pittsburgh, and associates retrospectively evaluated one 155 pediatric ALL patients identified at a single group between 2006 and 2012 for adverse activities. The authors in comparison the proportions of obese versus nonobese sufferers experiencing adverse activities.

The researchers found that in univariate analyses, treatment-requiring hypertension (17.5versus 6.1 percent; odds ratio, 3.27) and insulin-requiring hyperglycemia (25.0as opposed to 11.3percent; odds ratio, 2.62) passed off appreciably more often in obese sufferers. The incidence quotes for recurrent admission-requiring infections (incidence charge ratio, 1.64) and recurrent febrile neutropenia admissions (incidence price ratio, 1.53) were more for obese patients. Obesity became a risk factor for treatment-requiring hypertension, insulin-requiring hyperglycemia, and febrile neutropenia admission after accounting for blended age and National Cancer Institute chance status (odds ratios, 3.90, three.92, and 2.92, respectively).

“Obese kids with ALL represent a collection of sufferers at risk for bad outcomes due to treatment-related morbidity,” the authors write. “Early management of those adverse occasions and surveillance initiated at diagnosis may also mitigate danger on this distinct population of sufferers.”

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